Mephenesin and Gallamine Triethiodide in Tetanus
نویسندگان
چکیده
منابع مشابه
Fatal mephenesin intoxication.
This report describes a death related to the abuse of and intoxication by mephenesin. To the best of our knowledge, this is the first report case of lethal intoxication involving solely mephenesin and reporting mephenesin blood concentrations. The victim was a 48-year-old woman found unconscious at home. Resuscitation was unsuccessful. Toxicological analysis was performed on a blood sample coll...
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The effect of intravenously administered gallamine triethiodide (0.5-1.0 mg/kg) on cardiovascular function was estimated in patients anaesthetized with thiopentone, tubocurarine, nitrous oxide and trichloroethylene and artificially ventilated. A 40 per cent rise in heart rate and a 35 per cent rise in cardiac output were observed, with no significant change in stroke volume. A modest rise in me...
متن کاملSolvent substitution as a probe of channel gating in Myxicola. Effects of D2O on kinetic properties of drugs that occlude channels.
The effects of solvent substitution on the steady-state and kinetic properties of drugs (gallamine triethiodide) and ions (nonyltriethylammonium and Ba++) known to occlude Na+ and K+ channels have been examined and compared with the effects of D2O on unmodified channels. In general, we observed large isotope effects on the kinetics of occlusion at temperatures of 5 degrees C, but only minor eff...
متن کاملAcute generalized exanthematous pustulosis with mephenesin balm.
Mephenesin is an aromatic glycerol ether which decreases polysynaptic transmission in the spinal cord and brain stem. It is used as a skeletal muscle relaxant in the treatment of multiple sclerosis, Parkinson’s disease or acute muscle strain [1,2]. Mephenesin is associated to methyl nicotinate in the Décontractyl Balm. The methyl nicotinate has a rubifacient effect. Usually, the Décontractyl Ba...
متن کاملProcaine dosage and interaction with gallamine in children.
The dose of procaine (in mg/kg/min) necessary to obtain a satisfactory light level of general anaesthesia in children from 18 to 168 months old, diminishes with increasing age. There is no difference in the procaine requirement between sexes. When higher doses of procaine are injected, greater amounts of gallamine are needed to maintain satisfactory relaxation. Young children require higher dos...
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ژورنال
عنوان ژورنال: BMJ
سال: 1954
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.4885.445